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pentobarbital will reduce the level or effect of amlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will lessen the level or impact of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration. Potent or average CYP3A inducers may